|
TNF-A (TNFA; Tumor Necrosis Factor-Alpha)
Special interest causes the regulation of Nuclear factor kB, induced by the Tumor necrosis factor-alpha (TNF-A; TNFA). Cytokines of TNF-family to fulfill double functions in the cell. From one side, the TNF-stimulated intracellular cascade contributes to the activation of NF-kB and, therefore, to the stimulation of cellular proliferation and to the development of inflammation. From another side - the TNF-stimulated intracellular cascade activates the cascade of caspases, which conducts to Apoptosis (programmed cell death) of a cell - i.e. all that occurs in the psoriatic plaque.
TNF-A (Tumor necrosis factor-alpha) is one of the main effector molecules, secreted by many cells (macrophages, monocytes, neutrophils, basophils, eosinophils, T-cells and NK-cells, astrocytes, the cells of microglia, smooth musculature, fibroblasts, Langerhans's cells, Kupffer cells) in response to the bacterial infections, virus infections, fungus infections, and in response to the tumor growth.
Synthesis of TNF-A is induced by many factors, including IFN, IL-2, GM-CSF, Bradykinin (BK), immune complexes, while its production is inhibited by IL-6, TGF-b, and vitamin D3.
 |
