Uric Acid May Help to Combat the Central Nervous System Disorders, but May also Cause Gout and other Disorders
Most individuals with high levels of Uric Acid have no problems as this condition is not a disease.
However, in a small percentage of individuals - about 12% the excess of Uric Acid will turn into crystals and may lead to a disease called gout.
With gout the Uric Acid turned into crystals deposits in the spaces between the joints, tendons and ligaments. This causes inflammation that leads to excruciating pain.
In other people Uric Acid may deposit in the kidneys and form kidney stones.
Some studies prove and others disprove that the high levels of Uric Acid may cause the development of Hypertension and Cardiovascular disease.
You may ask: So where is the benefit? Aren't we talking about the "Benefits of Psoriasis" here? Is the risk of gout and kidney stones a benefit?
Well, here is the Trick: Most people with high levels of Uric Acid will never experience gout or kidney stones, because high levels of Uric Acid is not a disease.
Here is another Trick: Multiple studies show that Uric Acid may protect against Central Nervous System Diseases, such as Multiple Sclerosis, Parkinson's disease, Alzheimer's disease, Schizophrenia, and Stroke.
People with the high levels of Uric Acid, i.e. the people with gout or the people with psoriasis - never (or rarely) develop Multiple Sclerosis - a chronic Central Nervous System Disease in young adults during their most productive years.
This all is due to that Uric Acid is capable of preventing the chemical damage and maintaining the health of neurons (nerve cells).
High Levels of Uric Acid and Multiple Sclerosis in Particular
Mice inbred with Multiple Sclerosis - the EAE (Experimental Allergic Encephalomyelitis) - can be treated by a Uric Acid infusion.
Uric Acid is a known scavenger of peroxynitrite. Peroxynitrite, the product of the free radicals nitric oxide and superoxide, has been implicated in the pathogenesis of various inflammatory Central Nervous System disorders, including Multiple Sclerosis.
Uric Acid inhibits the following factors, associated with the Central Nervous System Disorders, and Multiple Sclerosis in particular:
- inactivates peroxynitrite mediated oxidation;
- inhibits the peroxynitrite-induced tissue damage;
- inhibits the blood-CNS barrier breakdown;
- inhibits the Central Nervous System inflammation.
Uric Acid scavenges free radicals in plasma and prevents lipid peroxidation. With concentration 10x more than Vitamin C, Uric Acid is one of the major natural antioxidants in a human.
According to multiple studies, serum Uric Acid levels are associated with the following diseases:
Diseases Associated with High Uric Acid Levels:
- Gout
- Kidney stones
- Hypertension
- Cardiovascular disease
Diseases Associated with Low Uric Acid Levels:
- Multiple Sclerosis
- Parkinson's Disease
- Alzheimer's Disease
- Schizophrenia
- Stroke
- Cancer (tumor development)
Some studies show a connection of the high levels of Uric Acid with the development of cardiovascular disease and kidney damage.
But other studies show that high Uric Acid levels may not be the cause, but the consequence of the cardiovascular disease.
The results of another study did not find any reliable connection between the cardiovascular disease and the Uric Acid levels.
Questions to You:
Would you rather have Gout or a Multiple Sclerosis?
Would you rather have Kidney Stones or a Parkinson's disease?
Would you rather have Hypertension or an Alzheimer's disease?
I would definitely prefer the diseases from the left side of the above questions...
CONCLUSION 1:
1. High levels of Uric Acid may protect the people with psoriasis from various Central Nervous System Diseases, such as Multiple Sclerosis, Parkinson's disease, Alzheimer's disease, Schizophrenia, and a Stroke.
2. High levels of Uric Acid may cause the development of Gout, Kidney stones, Hypertension and Cardiovascular disease in the people with psoriasis (this one is the only disadvantage from the whole list).
|
