Genetic Psoriasis Theory
Genetic Psoriasis Theory is presently one of the most reliable Psoriasis Theories. It is based on the multiple cases of family history of psoriasis. Relatives with psoriasis are revealed in 30-60% of people with psoriasis.
According to Genetic Psoriasis Theory, psoriasis is a general disease, which usually develops in genetically predisposed people. The gene for psoriasis has not been found.
Relatives with psoriasis are revealed in about 30-60% of people with psoriasis.
If parents without psoriasis have a child who has psoriasis, then the probability of psoriasis development in their other children will be about 17%.
If one of the parents has psoriasis, the possibility of their children to develop psoriasis will be about 25%.
If both parents have psoriasis, the possibility of their children to develop psoriasis will be 60-75%.
Genetic Psoriasis Predisposition
Metabolic Disorders
Invisible metabolic disorders (see Metabolic Psoriasis Theory) in the blood and skin (revealed with biopsy) precede visible skin Psoriasis Symptoms. These changes can be found in clinically healthy blood relatives with a family history of psoriasis.
Psoriasis itself is not transferred genetically. What is transferred genetically is the predisposition - nervous and endocrine systems changes, changes in the metabolism (i.e. enzyme metabolism, fat metabolism, proteins metabolism, cellular metabolism in the epidermis etc.), changes in the skin structure (disorder of keratinization, hyper-proliferation etc.), weak liver function etc. The predisposition will serve as a ground for development of psoriasis. Psoriasis will not always manifest visually. In order for psoriasis symptoms to appear in a genetically predisposed person, there has to also be a provoking factor, i.e. prolonged stress, infectious diseases (streptococcal or virus focal infection), environmental factors etc.
Genes and Chromosomes
Some locations of genes on chromosomes are also found to be responsible for the predisposition to psoriasis.
Locus PSORS 1
Locus (location of a gene on a chromosome) PSORS 1 seems to contain the cluster of alleles, connected with the development of psoriasis. Some of the alleles seem to be connected in particular with a severe course of psoriasis.
Human Leukocytes Antigens (HLA)
Human Leukocytes Antigen HLA-Cw6 also seems to have a connection with psoriasis. Antigens HLA-B13 and HLA-B17 are found to be connected with Plaque Psoriasis, and HLA-B27 - with Psoriatic Arthritis.
Retrovirus and the Genetic Code
Some scientists also consider the influence of a retrovirus on the genetic cell code (see Virus and Psoriasis Theory). If a specific virus penetrates into the cell's genetic material, correct genetic information is disrupted and there is created a new genetic material with altered properties. These changes indirectly or directly affect the biochemical structure of the blood, urine etc. As a result in the skin and blood it is possible to reveal special markers (some amino acids, enzymes etc.), which make the body predisposed to the appearance of psoriasis.
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