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Metabolic Psoriasis Theory is based on the data testifying about various metabolism disorders in the people with psoriasis.
Metabolism is the sum total of all the vital chemical processes that take place in a living cell or organism. In the metabolism certain substances are broken down and converted into energy while other necessary for life substances are synthesized.
Scientists note a slower metabolism in the people with psoriasis. There is noted a reduction in body temperature in the people with psoriasis, which also proves the slow metabolism.
Carbohydrate metabolism is disrupted in 60% of people with psoriasis. Approximately 25% of patients with psoriasis also have diabetes. Some scientists consider that carbohydrate metabolism disorders serve as the basis for Psoriasis Appearance, while others believe these disorders to be caused by psoriasis itself.
In the people with psoriasis there are observed the fluctuations of the content of micro cells, which participate in the oxidation-reduction processes.
Y. Kamei (1958) has revealed disorders of oxidation-reduction activity of the skin in the people with psoriasis.
Å. Neumann (1957) considered the increased oxidation-reduction activity of the epidermal cells (cells of the outer layer of the skin) to play the primary role in the development of psoriasis.
There are indications of a lowered level of oxygen in the blood in the people with psoriasis, which negatively affects the course of psoriasis.
The concentration of free radicals in the skin of people with psoriasis exceeds their content in the skin in people without psoriasis by as much as 3 times on the average. This proportion becomes normal closer to the clinical recovery from psoriasis.
Accelerated epidermal cell development can be confirmed by increased synthesis of glycogen in the skin of people with psoriasis, and especially in the psoriatic lesions.
The metabolism of vitamins with psoriasis is also disrupted, which decreases the adaptive abilities of the body. The content of Vitamin C is decreased in the blood, but it is increased in the skin; the content of the Vitamins A, B6, and B12 in the blood is reduced. Various shifts are also observed with the contents of copper, zinc and iron.
There is also found liver function disorder in the people with psoriasis. Liver function disorder seems to play a specific role, but not the main role in the pathogenesis of psoriasis.
In the progressive stage of psoriasis there is frequently noted an increased function of the thyroid and/or endocrine glands (see Hormones and Psoriasis Theory).
There is noted the absence of fat and perspiration on the psoriatic plaques and near them; it is restored when the psoriatic lesions regress.
There were discovered disorders of protein and of lipid metabolism in the people with psoriasis. The content of lipids and cholesterol in the people with psoriasis is increased. The increase in the lipids stimulates the overgrowth of layers of horny skin (keratosis).
Good therapeutic effect of a fat free diet proves the presence of the abnormal levels of certain fats in the people with psoriasis. A low-calorie diet usually helps to improve the state of psoriasis.
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