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Some scientists consider that psoriasis is caused by Nervous System disorders. Nervous System controls the actions and functions of the body. Psoriasis is believed to be based in particular on the blood vessels disorder - i.e. the disorder of the muscles in the walls of the blood vessels (mainly the arteries). Impaired muscular contractions (controlled by the Nervous System) create an artery spasm, due to which there deteriorates a blood supply to a certain section of skin and there psoriasis appears.
Researchers indicate the important role of the nerve endings trauma with psoriasis. Sadorai (1955) revealed an increase in the content of a neurotransmitter acetylcholine (transmits the electrical impulses from one nerve cell to another) in the nerve endings of the skin of the people with psoriasis. This allowed him to consider psoriasis a skin reaction caused by the nerves or the Nervous System disorders. This can also be confirmed by therapeutic effect achieved during the application of drug therapy for the normalization of the functions of Central and Peripheral Nervous System in the people with psoriasis.
Some scientists with the aid of Electroencephalography (EEG) revealed the disorders of the Brain Stem in the people with psoriasis. Brain Stem is a part of the Central Nervous System which controls basic, life-sustaining functions such as heart rate, blood pressure, breathing, body temperature, wakefulness and sleep, sexual functions and physical growth.
Electroencephalography (EEG) is the recording and the measurement of the electrical activity produced by the brain through electrodes placed on the scalp. There was noted the connection between the changes of the EEG and the peripheral blood vessel disorders, such as headaches, excessive sweating etc.
Other researchers see the neurosis-like states, noted in the people with psoriasis, as a result, and not the reason for psoriasis. Some forms of psoriasis can cause the dysfunction of the Peripheral Nervous System, nerves disorders and neurosis-like conditions.
The influence on the body from the "extraordinary stimuli" (Pavlov's term), or "the stress factors" (Selye's term), provoke the appearance of psoriasis or it's flare-ups. These factors include strong emotions, traumas, injuries, infections, intoxication and the like. There was established a relationship between stress factors and the severity of psoriasis. There are noted deviations in the state of the Nervous System in the people with psoriasis in the form of the disorder of the nervous processes - the predominance of the brake processes above the exciter processes.
In the progressive stage the state of the Nervous System in the people with psoriasis is characterized by depression, stress and anxiety. Unfortunately, the clinical regression of the psoriatic lesions is usually not accompanied by an improvement of the state of the Nervous System. Frequently the appearance of psoriasis can be connected with some psychological trauma. However the majority of scientists believe that psoriasis is not merely a psychosomatic disease (disease that is influenced by psychological or emotional factors).
The skin processes of the people with psoriasis have the predominance of the anabolic (with tissue buildup) processes, which activates the "psoriatic skin" cells. This process leads to an increase in the synthesis of nucleic acids (DNA - Deoxyribonucleic Acid; RNA - Ribonucleic Acid) and proteins.
It is still unclear whether psoriasis is the cause or the consequence of the disorders of the Nervous System. One thing is clear - people with psoriasis frequently have functional disorders of the Nervous System, which of course affects the course of psoriasis and the psoriatic relapses.
Nervous Theory of psoriasis is not proven.
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