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Palmoplantar Pustular Psoriasis (PPP) is a very rare form of psoriasis.
On the palms and soles there appear clusters of pustules filled with non-infectious pus. The pustules look like small, circumscribed elevations surrounded by red skin.
Pustular Psoriasis is believed to be triggered by medications, infections, or stress.
Although many dermatologists consider Palmoplantar Pustular Psoriasis (PPP) a type of psoriasis, many other dermatologists consider it an independent unit.
There was conducted a study of 216 people with Palmoplantar Pustular Psoriasis and 626 people with other dermatitises.
The data showed that 80% of the people with Palmoplantar Pustular Psoriasis were smoking at the time of the appearance of Palmoplantar Pustular Psoriasis, and among the people with other dermatitises only 36% of people were smoking at the time of the appearance of their dermatitis.
The risk of the appearance of Palmoplantar Pustular Psoriasis in smokers in comparison with the nonsmokers proved to be high.
One of the main roles in the pathogenesis of Palmoplantar Pustular Psoriasis may play neutrophils.
Neutrophils are a type of white blood cells of the immune system, involved in inflammation. The content of neutrophils increases in response to bacterial infection. Neutrophils can cause tissue damage for example in the late stage of an allergic reaction.
The quantity of neutrophils in the blood rises with smoking. Possibly this is how smoking affects Palmoplantar Pustular Psoriasis.
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