Type 1 and 2 Psoriasis

Some scientists separate Psoriasis into 2 types:

  1. Type 1 Psoriasis - associated with HLA;
  2. Type 2 Psoriasis - not associated with HLA.

So What is HLA?

HLA is an acronym for Human Leukocyte Antigens.

Human Leukocyte Antigens are genetic markers located on the surfaces of all white cells (leukocytes) and on the surfaces of most other cells in a human body. These markers identify body cells as "self" and the foreign cells as... well... "foreign". HLA molecules prevent the immune system from attacking the "self" cells and help to recognize the unmarked "foreign" cells. When the immune system finds an unmarked foreign cell, it starts to attack it.

HLA molecules are inherited from ones parents and therefore the chance of having the same HLA type is the greatest between siblings. HLA markers are used to determine tissue compatibility when searching for a donor within ones family or from the volunteer donors in order to match donated organs or bone marrow with the transplant recipient.

HLA have 2 sets of cell surface molecules - HLA class I and HLA class II. The major groups are: HLA-A, HLA-B, HLA-C, HLA-DR and HLA-DQ. There are two A numbers, two B numbers, two C numbers, two DR numbers and two DQ numbers. Altogether there are more than a hundred different HLAs.

Some HLA markers are associated with the increased risk of developing different Types of Arthritis, Type 1 Diabetes etc.

HLA and Psoriasis

Type 1 Psoriasis

  • Type 1 Psoriasis begins at a young age - usually in people between 14-25 years old.
  • Type 1 Psoriasis is associated with the HLA system (the specific genetic HLA markers were revealed in 85.3% of the cases).
  • Type 1 Psoriasis is believed to be caused by the breakdowns in the immune system transmitted genetically.
  • About 65% of people with psoriasis have Type 1 Psoriasis.
  • Type 1 Psoriasis predominantly affects the skin.

Type 2 Psoriasis

  • Type 2 Psoriasis begins later - usually in people older than 40 years old.
  • Type 2 Psoriasis is not associated with the HLA system. Family history of psoriasis in the case of Type 2 Psoriasis is also absent.
  • Type 2 Psoriasis begins spontaneously.
  • About 35% of people with psoriasis have Type 2 Psoriasis.
  • Type 2 Psoriasis predominantly damages the nails and the joints.
Comments (7)add comment
aditya: ...
I have this problem for last two years.I tried lots of medicines but no of use.I am trying only Ayurvedic medicines and results are best.My psoriasis is recovering and i am feeling happy.I would like to suggest that dont go for any other medicines go for only Ayurvedic.This disease should be cured internally .Keep your stomach clean .Dont get stressed .Do Prnayam and Yoga it is thousand times better than those steroids.You will get good results soon within a week it starts alleviating and in a month only it is cured depends how much you practice it.thats all

If you want to share something this is my email id-- This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
1

January 18, 2012
teresa: ...
I am praying complete healing over you as I read your post. Call out to Jesus and he will be there to guide you thru this.
2

January 18, 2012
Ruth Ann Watson: ... http://www.bafarmsoap.com
Hi, Birkat Adonai Farm has a treatment plan for severe Psoriasis and Eczema. We have had great results from our private customers, adults and children, and now we are going online. I do know that our products work, and it is in my heart to help others with severe skin conditions. Look over the website and if you have any questions about our products and how they work, please feel free to call me. We do not use any chemicals or colorings. www.bafarmsoap.com This is not spam, but a genuine concern for psoriasis and arthritis patients. God Bless!
3

December 30, 2011
Aginoth: ...
Would be helpful to have sources for the info above, names of the "Scientists" maybe?
4

February 19, 2011
Kavita: ...
My mom 56 yrs old she suffering Psoriasis in 8 yrs very two year she suffering with the disease.Can give some advice.
5

November 27, 2010
~Psoriasis-Aid Admin~: ...
Hi!

I am sorry for being so slow (day job)...

And I'm truly sorry to hear that your psoriasis is so bad!

Here are 2 things you may want to try: diets or biologics.

---------------
Diets
---------------

There are dozens of diets: a watermelon diet, Kombucha diet, Pagano psoriasis diet, and therapeutic fasting - you can find information about all these diets on this website, just look at the bottom of the right menu.

There's also "candida diet" (just google it), and it's based on the assumption that people with psoriasis have candida in their intestines, which needs to be killed in order to help psoriasis.

Anyway, any good diet or fasting will help you, if done right.

---------------
Biologics
---------------

You have probably heard of Caridee English, the winner of America's Next Top Model in 2006. Caridee has psoriasis, and she has gotten rid of it with biologics!
Biologics are expensive, and they possess side-effects (lowered immunity), but they almost always work!

Either way, I hope that between diets and biologics, you will find something that will help you!

Keep trying, and remember that there're roughly 150.000.000 (150 million) of us (psoriasis sufferers) in the world.

Good luck!

Psoriasis-Aid Admin
6

August 09, 2009
can anyone help me: ...
i am a 22 year old male from sydney aus. i got psoriasis first when i was 18 only on my elbows. it was very rare then all off a sudden at 21 an june 2008 came out neally 90 pecent of my body: hands feet knees legs dots on abdomen chest face ears ,big red scabby patches on back same as elbow elbows, that were more then 10 cm s in diametmetre. i evan had it in my finger nail. it went in october so 4 monthes later and a little bit came back on my elbow. then feb this year , in one week i had got it svearly on my hands arm lags back shoulder and i have dry ears.since then iv tried thousands od dollars in treatments and and nothing has worked, every miricle cream for psoriasis never worked. Its very depressing and the dermatologist are a months waiting list for me to see them each time(they usualy give me another perscription to some new drug that never works.so im over 5 monthes now with it again i cant go in public much cause its yuk. if there is anyone that has suffered it aswell and has any useful information that can may help me relieve my condition if not put it inremission i have tried everything ivan uv theropy. email me i will appreciate it with all my hart
This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
7

July 25, 2009

Write comment
smaller | bigger

busy
Poll: Your Favorite Psoriasis Treatment?
Please note: The contents on Psoriasis-Aid.com is intended for informational purposes only. Please consult your doctor before beginning any psoriasis treatment.
BIO
BIO
BIO 
Psoriasis-Aid.com - Home